Abstract Review With Patrick Horne

Clinical Vignettes

July 2025

Join Patrick Horne, NP from the University of Florida, as he reviews key findings from a recent SLLD abstract titled “Validation of the Worst Itch Rating Score (WI-NRS) and Related Patient-Reported Outcomes (PROs) to Assess the Severity and Impact of Pruritus in Patients with Primary Biliary Cholangitis (PBC).” This session explores the significant burden of cholestatic pruritus on PBC patients and the need for better measurement tools. Drawing on data from the phase 2B GLIMMER study, Patrick discusses the psychometric validation of the WI-NRS, a modified 7-day recall PBC-40, and other PROs such as sleep interference and fatigue NRS tools. The results demonstrate strong reliability and clinical relevance of these tools for assessing pruritus severity and quality of life impacts in PBC—providing a foundation for their use in the upcoming phase 3 GLISTEN study. Whether you’re a hepatology specialist or an advanced practice provider, this podcast delivers actionable insights into patient-centric endpoints for PBC clinical trials.